Hope Australia

1. Ozone dissolves in the water of the plasma and generates hydrogen peroxide and lipoperoxides which behave as secondary messengers: almost instantaneously, they enter into the erythrocytes and activate a number of biochemical pathways. The ROS are almost immediately reduced (H2O2 to water and ROO to hydroperoxide) mostly at the expense of the GSH. The erythrocytes, for a brief period, enhance the delivery of oxygen into ischemic tissues because of a shift to the right of the oxygen-haemoglobin dissociation curve due either to a slight decrease of the intracellular pH (Bohr effect) or/and an increase of 2,3-DPG levels.

2. The second modification occurs in the bone marrow when submicromolar amounts of LOPs reach various organs, among which the bone marrow, where they can influence the differentiation of erythroblastic linage. It is emphasized that each treatment represents a calculated, very transitory oxidative stress that, by activating the adaptive mechanism, results in the genration of erythrocytes with improved biochemical characteristics. The 'supergifted erythrocytes' due to a higher content of 2,3-DPG and antioxidant enzymes during their life time, become able to deliver more oxygen into ischemic tissues (Tylicki, 2004). Price A$1,250 + Freight +GST within Australia.

 Home